All Courses
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High-Throughput Screening
During this course, the potential of modern analytical and biological screening techniques used in target, hit and lead discovery will be discussed. The emphasis will be on the treatment of advanced sample preparation techniques (i.e. automation, high-throughput / combinatorial chemistry, miniaturization), biological and immunological high throughput screening assays and advanced separation methods. Also, the so called “Omics” will be discussed (e.g. proteomics and metabolomics). These techniques will be discussed in relation with pharmacokinetic studies and the applicability of the various techniques within the various stages of target discovery, hit screening, ADME(tox), and early lead discovery. Finally, miniaturization approaches will be dealt with.